We found that endothelial cells repress senescence-associated Senescence but, surprisingly, without a typical senescence secretory response. Induces acute IL-6 release through reactive oxygen species-mediated p38 activation in vitro. We used tissue-specific knockout mice to demonstrate thatÄ®ndothelial production of the proinflammatory cytokine IL-6 promotes chemoresistance and show that the chemotherapeutic doxorubicin In vitro and in vivo despite the induction of cellular senescence. Here, we detail an acute chemotherapy-induced secretory response that is self-limiting However, how these damage responses are regulated (both induced and resolved) to preserve tissue homeostasis and prevent chronic Therapy-inducedÄamage of normal cells can alter the tumor microenvironment, causing cellular senescence and activating cancer-promoting inflammation. Cancer therapy targets malignant cells that are surrounded by a diverse complement of nonmalignant stromal cells.
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